Treatment of breast cancer molecular

Molecular breast imaging is a test that uses a radioactive tracer and special camera to find breast cancer. Rather than simply taking a picture of a breast, molecular breast imaging is a type of functional imaging. This means that the pictures it creates show differences in the activity of the tissue. Tissue that contains cells that are rapidly growing and dividing, such as cancer cells, appears brighter than less active tissue.
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Breast cancer - Diagnosis and treatment - Mayo Clinic

Metrics details. Optimizing treatment through microarray-based molecular subtyping is a promising method to address the problem of heterogeneity in breast cancer; however, current application is restricted to prediction of distant recurrence risk. This study investigated whether breast cancer molecular subtyping according to its global intrinsic biology could be used for treatment customization. Gene expression profiling was conducted on fresh frozen breast cancer tissue collected from patients in conjunction with thoroughly documented clinical data. A method of molecular subtyping based on probe-sets was established and validated. Statistical analysis was performed to correlate molecular subtypes with survival outcome and adjuvant chemotherapy regimens.
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Breast Cancer Treatment

April 13, , by Louis M. Staudt, M. Owing to advances in our ability to sequence and understand the human genome, traditional descriptions of cancer are being superseded by a new classification framework that focuses on the genetic abnormalities and molecular derangements of malignant tumors. This conceptual transformation has the potential to alter diagnostic categories, enhance treatment strategies, enable early detection and prevention, and improve outcomes for cancer patients.
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Until the late s nearly all drugs used in cancer treatment with the exception of hormone treatments worked by killing cells that were in the process of replicating their DNA and dividing to form 2 new cells. These chemotherapy drugs also killed some normal cells but had a greater effect on cancer cells. Targeted therapies work by influencing the processes that control growth, division, and spread of cancer cells, as well as the signals that cause cancer cells to die naturally the way normal cells do when they are damaged or old. Targeted therapies work in several ways.
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