National surgical breast and bowel project
We have a more than year history of designing and conducting clinical trials that have changed the way breast cancer is treated, and, more recently, prevented. It was the NSABP's breast cancer studies that led to the establishment of lumpectomy plus radiation over radical mastectomy as the standard surgical treatment for breast cancer. We were also the first to demonstrate that adjuvant therapy could alter the natural history of breast cancer, increasing survival rates, and the first to demonstrate on a large scale the preventive effects of the drug tamoxifen in breast cancer. Since its beginning the NSABP has enrolled more than , women and men in clinical trials in breast and colorectal cancer. We are headquartered in Pittsburgh, Pennsylvania and have research sites at nearly major medical centers, university hospitals, large oncology practice groups, and health maintenance organizations in the United States, Canada, Puerto Rico, Australia, and Ireland.
Bernard Fisher (scientist)
Bernard Fisher (scientist) - Wikipedia
Now, close to 60 years later, the treatment of breast and bowel cancer has changed dramatically in large part because of the trials conducted by the NSABP. These trials have had a profound impact on our understanding and treatment of these diseases. Today there are member institutions with more than affiliate centers located throughout the United States, Canada, Puerto Rico, and other international sites. Many of the member institutions are university hospitals or large comprehensive cancer centers, but the majority of these sites are community-based institutions. This allows patients the opportunity to enter studies without the burden or cost of travel to academic centers. The initial studies of the NSABP focused on the effectiveness of thiotepa, 5-FU fluorouracil , radiotherapy, or oophorectomy in the adjuvant treatment of patients with breast cancer following radical mastectomy 1.
In this stage, the tumor has started to invade the wall of the colon, but not yet spread to other distant organs. Two-thirds of these cases, or more than 95,, will be cancers of the colon," said Norman Wolmark , M. We are keen to explore if regorafenib could help patients at earlier stages of the disease. If positive, Bayer may use the results as the basis for regulatory filings to health care authorities to support an expanded indication for the use of Stivarga in this earlier stage of disease.
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