Breast cancer and breast size

Metrics details. While some factors of breast morphology, such as density, are directly implicated in breast cancer, the relationship between breast size and cancer is less clear. Breast size is moderately heritable, yet the genetic variants leading to differences in breast size have not been identified. To investigate the genetic factors underlying breast size, we conducted a genome-wide association study GWAS of self-reported bra cup size, controlling for age, genetic ancestry, breast surgeries, pregnancy history and bra band size, in a cohort of 16, women of European ancestry. These results provide insight into the genetic factors underlying normal breast development and show that some of these factors are shared with breast cancer. While these results do not directly support any possible epidemiological relationships between breast size and cancer, this study may contribute to a better understanding of the subtle interactions between breast morphology and breast cancer risk.
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Breast Tumor Size and Staging

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Breast Cancer Treatment (Adult) (PDQ®)–Patient Version - National Cancer Institute

We respect your privacy. FRIDAY, July 6, — Scientists have long known that certain breast factors like density and asymmetry are associated with increased risk of breast cancer. Researchers looked at data from more than 16, females of European ancestry, who were customers of the genetic-testing company 23andMe, based in California. The women had completed surveys listing bra size, age, genetic ancestry, and personal health history. Two of the seven variations had been previously implicated in developing breast cancer. In each case, the SNP is linked to both increased breast size and increased cancer risk. A third variation is related to breast density and cancer risk.
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Size of the Breast Cancer

Researchers at a commercial DNA testing service say they have found a handful of genes that help determine whether a woman spends her life as an A cup or a D. In a study published in the journal BMC Medical Genetics , Eriksson and his colleagues analyzed data from more than 16, female customers who had previously had their genetic makeup examined. The researchers were looking for single nucleotide polymorphisms, or SNPs, which are variations in DNA that occur when a single nucleotide in a sequence is altered. Some SNPs have no impact on cell function; others can predispose people to certain traits or illnesses.
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Dense breasts have less fatty tissue and more non-fatty tissue. Breasts that aren't dense have more fatty tissue and less non-fatty tissue. Mammograms can help you and your doctor determine how dense your breasts are. A large study suggests that women with dense breasts are more likely to be diagnosed with breast cancer and the breast cancer is likely to be more aggressive.
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